摘要
目的 :观察胸腺肽α1联合前列地尔治疗慢性重症肝炎的疗效。方法 :慢性重症肝炎 70例 ,分成治疗组 35例 ,对照组 35例。对照组用前列地尔待支持、保肝疗法 ;治疗组在此基础上加胸腺肽α1治疗 ,3m后检测血清胆红素、谷丙转氨酶、凝血酶原活动度等水平。结果 :治疗组总有效率为 80 0 % ,对照组总有效率为4 5 1% ,两组比较差异有显著意义 (P <0 0 5 ) ;治疗组与对照组治疗前各项生化指标比较无显著性意义 (P <0 0 5 ) ;治疗后两组的生化指标均有所下降 ,两组比较差异有非常显著性意义 (P <0 0 1)。结论 :胸腺肽α1联合前列地尔能显著减轻肝脏的损伤程度 ,而且患者耐受性好 。
Objective:To observe the therapeutic effect of thymosin α\-1(T α\-1)combined with Alprostail in the tresrment of chronic hepatitis.Mothods:Seventy patients with severe hepatitis,who were randomly divided into treatment group( n =35)and control group( n =35)received Alprostail for three months.Those in the treatment group received T α\-1 coincidently.Three months later,the levels of serum?TSB,ALT and PTA were measured.Results:At the end of trearment,the levels of TSB and ALT were decreased in the treatment group as compared with those in the control group( P <0 01).In the treatment group,total effective rate was 80 0% while that in the control group was 45 1% respectively with the difference being significant ( P <0 05).Conclusion:The therapy of T α\-1 combined with alprostail can obviously alleviate the liver injury and the patients with chronic severe hepatitis.
出处
《武警医学院学报》
CAS
2003年第3期204-205,208,共3页
Acta Academiae Medicinae CPAPF
