摘要
目的 :探讨解毒祛瘀滋阴法对系统性红斑狼疮 ( SLE)接受类固醇激素治疗后引起血脂异常的防治作用。方法 :临床筛选女性 SLE患者 46例 ,随机分为初病组、中西医结合组和西药组 ;并按强的松剂量不同随机分为强的松低、中、高剂量组 ;另选 2 0例健康女性做正常对照组。观察各组的甘油三酯 ( TG)、总胆固醇 ( TC)、高密度脂蛋白 ( HDL- c)、低密度脂蛋白 ( LDL- c)、极低密度脂蛋白 ( VLDL- c)和脂蛋白 a( LPa)的水平。结果 :1初病组与正常组比较 ,各项指标差异无显著性意义 ;中西医结合组与西药组比较 ,TC、LPa差异均有显著性意义 ( P<0 .0 1、P<0 .0 5 ) ;2强的松中剂量组和高剂量组的 TC均明显高于正常组和强的松低剂量组 ( P<0 .0 5 ) ;强的松低剂量组与正常组比较 ,TC、HDL- c、LPa、VLDL- c、LDL- c之间差异均无显著性意义 ( P>0 .0 5 )。结论 :解毒祛瘀滋阴法能有效防治 SLE类固醇性血脂异常。
Objective: To study the effect of Jieduquyuziyin methods on Corticosteroid Hyperlipemia in patients and its mechanism.Methods:Forty six patients and twenty normal women,according to the difference of therapeutics, they were chosen and divided into four groups: the normal group, the first therapy group, the prednisone group and the TCM group. According to the dosage of the prednisone,they were divided into the lower, middle and higher dosage of prednisone group.The change of the level of serum TC, TG, HDL c, LDL c, VLDL c, Lpa of patients were observed and compared.Results: ①The level of serum TC of the middle and higher dosage of prednisone group were higher than that of the lower dosage of prednisone group ( P <0.05) ;There were no difference in level of serum LDL c, HDL c, VLDL c and Lpa between lower dosage of prednisone group and the normal group ( P >0.05) ;②There were no significant difference in level of all kinds serum index between the normal and first therapy group( P >0.05) ;There were significant difference between TCM group and prednisone group in the level of serum TC and LPa( P <0.05); Conclusion:Jieduquyuziyin methods can prevent and cure corticosteroid hyperlipemia in cases of SLE.
出处
《浙江中西医结合杂志》
2003年第6期336-338,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
