摘要
本文研究了川芎嗪对实验性肾功能衰竭(CRF)大鼠的治疗作用,结果表明川芎嗪给药组血清肌酐,尿素氮和尿蛋白明显下降,推测川芎嗪能够明显改善肾功能。而甘油三酯和胆固醇有升高的趋势,提示在治疗CRF的同时要纠正高脂蛋白血症的发生,同时测定了肾皮质和肾髓质的6-keto PGF_(1α)和TXB_2的含量,发现川芎嗪能够显著增加6-keto PGF_(1α)/TXB_2的比值,提示可能是通过影响肾皮质和肾髓质的PGs分泌而使CRF得到进一步的缓解。
In the experimental CRF rats, the influences of IMP on the contents of serum creatinine,blood urea nitrogen, urine protein, triglyceride and cholesterol were studied.The results showed that serum creatinine, blood urea nitrogen and urine protein decreased significantly in the TMP treatment rats ( P<0.001 ) .But triglyceride and cholesterol increased remarkably ( P<0.001 ),while in CRF rats the TMP can elevate the 6-keto PGF1a/TXB2 rate of renal cortex and medulla obviously. All those results suggested that TMP might improve the kidney function of CRF rats through in fluen-cirig the PGs secretion from the renal cortex and medulla, meanwhile prevent the incidence of hyperlipoproteinemia.
出处
《基础医学与临床》
CSCD
1992年第2期53-56,共4页
Basic and Clinical Medicine
基金
自然科学基金资助
编号:生C-38970833
关键词
川芎嗪
肾衰竭
Tetramethypyraziae(IMP) Chronic Renal Failure (CRF) 6-keto PGF1α TXB2
