摘要
目的 :探讨新生儿葡萄糖 - 6-磷酸脱氢酶 (G - 6-PD)缺陷病并急性溶血的临床诊治特点及预后。方法 :回顾性分析 4 5例新生儿G - 6-PD缺陷病并急性溶血的诱因、诊治情况 ,并对早产儿组与非早产儿组其胆红素脑病发生率及死亡率进行比较。结果 :诱因以感染占首位 ( 5 6% ) ,胆红素脑病发生率高 ( 9% ) ,早产儿组与非早产儿组对照其胆红素脑病发生率 (P <0 .0 5 )及死亡率 (P <0 .0 1)均有显著差异。结论 :①感染是G - 6-PD缺陷病并急性溶血的首位诱因。②胆红素脑病可在血清胆红素值较低 (最低为 30 2umol/L)的水平上发生 ,早产儿发生率高。③除常规治疗外 ,可换血 ,但要严格掌握指征。④G - 6-PD缺陷病合并感染、出血、酸中毒等因素 ,尤其是早产儿预后极差 ,更应予及早重视 (如防治感染、止血、纠酸等 )。
Objective:To investigate the clinical characteristic and prognosis of newborn G-6-PD deficiency complicating acute hemolysis. Methods:Clinical and prognostic data were analyzed in 45 newborns with G-6-PD deficiency complicating acute hemolysis, compared the incidence of bilirubin encephalopathy and mortality between premature group and non-premature group.Results:Infection is the major cause of all(56%).The incidence of bilirubin encephalopathy is high(9%).The incidence of bilirubin encephalopathy(P<0.05)and mortality(P<0.01) had significant differences between premature group and non-premature group.Conclusion:Infection is the major cause of newborn G-6-PD deficiency complicating acute hemolysis.Bilirubin encephalopathy may occurs in lower level of plasma bilirubin(the lowest value is 302umol/L).The incidence of premature bilirubin encephalopathy is high.Blood transfusion may put to use strictly besides routine treatment.Prognosis is worse in newborn G-6-PD deficiency complicating infection,hemorrhage,acidosis,especially premature.
出处
《河北医学》
CAS
2003年第4期326-328,共3页
Hebei Medicine
