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格列美脲与二甲双胍联合治疗2型糖尿病的临床观察 被引量:1

Clinical evaluation of glimepiride and metformin in the treatment of type 2 diabetes
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摘要 目的 :评价新一代磺酰脲类药物 (格列美脲 )与二甲双胍 (格华止 )联合治疗 2型糖尿病(DM)的疗效。方法 :新诊断的 2型DM患者 86例 ,服用格列美脲 1~ 6mg/d ,治疗 6周 ,空腹及餐后 2h血糖仍未达标者为 38例 ,加用二甲双胍 15 0 0mg/d ,治疗 6周。结果 :格列美脲降低血糖的达标 (理想控制水平 )率为 5 5 .8% ;格列美脲联合二甲双胍 ,达标率提高至 89.4 7%。结论 :格列美脲与二甲双胍联合治疗 2型糖尿病能有效地控制血糖 ,并有降低血脂的作用 ,且不增加体重。 Objective: To evaluate the efficacy of new antidiabetic agent glimepiride and metformin in the treatment of type 2 diabetes.Method: 86 cases of newly diagnosed type 2 diabetic patients took glimepiride 1~6mg/d,treating for 6 weeks,fasting and 2h postprandial blood glucose of 38 cases were not still reached level, metformin of 1500 mg/d was added up to, treating 6 weeks.Results: Blood glucose controlled reaching ideal level rate of glimepiride was 55.8%; reaching ideal level rate of glimepiride and metformin was increased to 89.47%.Conclusion: Glimepiride and metformin effectively control blood glucose of type 2 diabetes,which fall grease and don't increase avoirdupois.
出处 《河北医学》 CAS 2003年第4期297-298,共2页 Hebei Medicine
关键词 格列美脲 二甲双胍 联合治疗 2型糖尿病 临床观察 Glimepiride Metformin Curative effect
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  • 1Raptis, Hatziagelaki E, Dimitriadis G, et al. Comparative effects of glimepiride and glibenclamide on blood glucose, c- peptide and insulin concentrations of the fasting and postprondial state in normal men[ J ]. Exp Clin Endocrinol diabete, 1999, 107: 350 -355.
  • 2Lutz TA, Estermanu A, Hage S. et al. Depolarization of the liver cell membrane by meffomlin[J]. Biochim Biophys Acta, 2001.

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