摘要
本文研究了一种适合于卤素标记化合物的高分子氧化剂的合成及其性能,研究了适合于某些卤代放射性药物合成的高速、无载体产物的同相标记法和固相反应器。用于肿瘤探针的药物带电诺丹明和肾功能显像剂胆固醇在固定化后,将这两种药物进行固相法碘标记并对产物进行了鉴定,得到了放射化学纯度大于95％,放射性回收率高于96％的标记化合物,实现了5分钟内完成放射性标记药物无需分离就可得到极高放化纯产物的高速标记法。本文还对其它能生成有机汞化物的固相标记法进行了讨论。
The synthesis and the property of polymer oxidizing agent which is suitable for halogen radiolabeling, a high-speed, no-carrier-added solid phase labeling method and its reactor are describled. An electrified rhodamine and oholestrol were radiolabelled by the method0 and their produets were identified. The radiochemical purity of each radiolabelled compound was more than 95％ and radioactive recovery ratio was more than 96％. It realized high-speed labeling of the halogenated radio-pharnaaceuticals because the whole procedure was completed in five minuts. The solid phase labeling method for the substance that can form organomeroury compound is discussed.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1992年第4期397-404,共8页
Acta Chimica Sinica
