摘要
目的 研究无抽搐电休克治疗 (MECT)引起呼吸恢复时间延长患者的药物使用情况。方法 将MECT通电后呼吸恢复时间达≥ 6min的患者为延长组 ,<6min呼吸恢复的患者为对照组 ,每组各 72例。对两组MECT前 3天用药的方式、频度、剂量进行调查和比较。结果 (1)延长组和对照组 (有 2例未用药 )单一用药分别为 9例 (12 % )和 5 6例 (78% ) ,联合用药分别为 6 3例 (88% )和 14例 (19% ) ,差异有非常显著性 (t=72 35 ,P <0 0 1)。 (2 )两组使用频度在前 5位的药物依次为 :氯氮平(33% )、氯丙嗪 (2 8% )、氟哌啶醇 (2 6 % )、舒必利 (19% )、抗抑郁药 (19% )。在单一用药上 ,延长组和对照组 (以下按此顺序 )用氯氮平分别为 4例和 11例 ,氯丙嗪 0例和 10例 ,氟哌啶醇 1例和 7例 ,舒必利0例和 10例 ,抗抑郁药 2例和 5例 ,其他精神药物 2例和 4 5例 (t=6 7,P <0 0 1) ;在联合用药上 ,延长组和对照组用氯氮平分别为 32例和 1例 ,氯丙嗪 2 3例和 7例 ,氟哌啶醇 2 7例和 2例 ,舒必利 14例和4例 ,抗抑郁药 15例和 5例 ,其他精神药物 34例和 10例 (t=4 0 0 ,P <0 0 1)。 (3)精神药物使用剂量 :延长组为 2 0 0～ 16 0 0mg/d ,平均 (6 77± 35 1)mg/d ;对照组为 0～ 10 0 0mg/d ,平均 (2 2 9± 2 2 4 )mg/d ,差异有非常?
ObjectiveTo study the effect of pharmacotherapy on the respiratory resuming time after modified electric convulsive treatment (MECT). MethodsAccording to whether the respiratory resuming time ≥6 minutes or not after MECT, the subjects were divided into elongation or control group, with 72 in each group. The administration patterns, frequency, and dosage of the medications during 3 days before MECT were compared between the two groups. Results(1) The subjects receiving single- and combined-medication in the elongation group were 9 and 63, whereas 58 (2 medication-free) and 14 in control group, respectively ( P <0.01). (2) The mean dose of psychopharmaceutical was (677±351)mg daily (range: 200-1 600 mg/d) in the elongation group, which was significantly higher than that in control group [mean: (229±224) mg/d; range: 0-1 000 mg/d; t =8.48, P <0.01]. ConclusionsIt is suggested that the subjects be administered either single medication with a low dosage, or discontinuation of medication before MECT, which is helpful for avoiding elongation of respiratory resuming time.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2003年第2期91-93,共3页
Chinese Journal of Psychiatry
