摘要
钠/碘转运体(sodium/iodidesymporter,NIS)是一种糖化膜蛋白,是甲状腺组织及非甲状腺组织摄取碘的分子基础。NIS不仅分布在甲状腺细胞基底膜上,也存在于胃、前列腺、子宫等组织中。通过增加或抑制其在甲状腺组织中的表达,可以诊断和治疗甲状腺疾病。另外,选择性地增加或导入NIS基因,利用放射性碘诊断和治疗非甲状腺肿瘤也显示出令人鼓舞的结果。NIS基因还可以作为影像报告基因,用以测定动物模型及转基因试验中目的基因的表达情况。所以,深入研究NIS,不仅有利于提高对甲状腺功能调控和甲状腺疾病的认识水平,而且具有十分重要的临床实用价值。
The sodium iodide symporter(NIS)is a membrane glycoprotein that mediates iodide uptake in the thyroid gland and several extrathyroidal tissues.In addition to thyroid tissues,the expression of NIS is found in stomach,prostate,placenta and so on.Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders.However,some extrathyroid tissues also take up radioiodine,contributing to unwanted side effects of radioiodine therapy.Now that the molecule of NIS has been cloned and characterized,it may be possible to develop novel strategies to differentially modulate NIS expression and activity,enhancing it in target tissues and impeding it in others.It is also important to explore the use of NIS as an imaging reporter gene to monitor the expression profile of the transgene in transgenic mouse animal models and in patients undergoing gene therapy clinical trials.
出处
《国外医学（放射医学核医学分册）》
2003年第2期56-58,65,共4页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词
糖化膜蛋白
钠/碘转运体
甲状腺疾病
诊断
治疗
sodium iodide symporter
thyroid
extrathyroidial tissue
radioiodide therapy
breast cancer
gastric disease
imaging reporter gene
