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结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布 被引量：1

Intercellular adhesion molecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer
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摘要 用ICAM-1(Intercellularadhesionmolecule-1)和S-100免疫组织化学技术,Ishigami分级记数和统计学分析方法,研究结肠癌淋巴转移时细胞间粘附分子-1在淋巴管内皮细胞中的表达和树突状细胞(Dendriticcells,DCs)的分布.正常结肠组织淋巴管内皮细胞ICAM-1表达阴性,癌组织淋巴管内皮细胞ICAM-1表达呈阳性.随着癌组织浸润深度的增加,ICAM-1阳性淋巴管数目逐渐增多(P<0.01).当肠周淋巴结有癌转移时,ICAM-1阳性淋巴管明显多于无癌转移组(p<0.01);与ICAM-1的表达相反,树突状细胞(DCs)局部浸润强度与癌组织浸润深度呈负相关(r=-0.62,p<0.01),肠周淋巴结无癌转移组DCs数目多于有淋巴结转移组(P<0.01).ICAM-1的表达和DCs的分布与结肠癌的浸润和淋巴转移有密切关系,并对结肠癌的治疗和预后均有重要的临床意义. The expression of Intercellular adhesion molecule1 (ICAM1) in lymphatics endothelial cells and the distribution of Dendritic cells (DCs) as lymphatic metastasis of colon cancer were investigated by ICAM1 and S100 immunohistochemics, Ishigami staging calculation and statistics analysis. ICAM1 expression of lymphatic endothelium is negative in normal colon and positive in conlon cancer, respectively. The number of ICAM1 positive lymphatics increases gradually with the depth of cancer invasion (P<0.01). In the group of cancer metastasis of colon, the number of ICAM1 positive lymphatic in lymph node is greater than in the group of no metastasis (p<0.01). In opposite of ICAM1's results, there is a negative correlation between the number of DCs and the depth of cancer invasion (r=-0.62,p<0.01). The number of DCs in no metastasis group was more than that of in metastasis group (p<0.01). The expression of ICAM1 and the distribution of DCs have relation with the invasion and metastasis of colon cancer, and they show important clinical significance in the therapy and prognosis of colon cancer.
作者 宿志弘 李继承 季一鸣
机构地区 浙江大学细胞生物学研究所 仙居人民医院
出处 《浙江大学学报（理学版）》 CAS CSCD 2003年第3期327-331,共5页 Journal of Zhejiang University（Science Edition）
关键词 结肠癌 淋巴转移 细胞间粘附分子 树突状细胞 ICAM-1 基因表达 colon cancer ICAM-1 dendritic cells S-100 lymphatic metastasis
分类号 R735.35 [医药卫生—肿瘤] R730.21 [医药卫生—肿瘤]
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参考文献9

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同被引文献14

  • 1Yonemasu H,Takashima M,Nishiyama KI,Ueki T,Yao T,Tanaka M,Tsuneyoshi M.Phenotypical characteristics of undifferentiated carcinoma of the pancreas:a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin,alpha catenin and beta catenin expression.Oncol Rep 2001; 8:745-752
  • 2Cursiefen C,Schlotzer-Schrehardt U,Kuchle M,Sorokin L,Breiteneder-Geleff S,Alitalo K,Jackson D.Lymphatic vessels in vascularized human corneas:immunohistochemical investigation using LYVE-1 and podoplanin.Invest Ophthalmol Vis Sci 2002; 43:2127-2135
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  • 5Natali P,Nicotra MR,Cavaliere R,Bigotti A,Romano G,Temponi M,Ferrone S.Differential expression of intercellular adhesion molecule 1 in primary and metastatic melanoma lesions.Cancer Res 1990; 50:1271-1278
  • 6Lefor AT,Fabian DF.Enhanced cytolytic activity of tumor infiltrating lymphocytes (TILs) derived from an ICAM-1 transfected tumor in a murine model.J Surg Res 1998; 75:49-53
  • 7Wilting J,Tomarev SI,Christ B,Schweigerer L.Lymphangioblasts in embryonic lymphangiogenesis.Lymphat Res Biol 2003; 1:33-40
  • 8Prevo R,Banerji S,Ferguson DJ,Clasper S,Jackson DG.Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium.J Biol Chem 2001; 276:19420-19430
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浙江大学学报（理学版）
2003年 第3期

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