摘要
目的 研究雄激素受体(AR)在前列腺癌(PCa)组织中的表达,探讨AR与PCa的关系。方法 采用免疫组织化学SP法检测60例PCa标本和40例正常前列腺组织AR的表达。结果 PCa组AR表达明显低于正常的列腺对照组(p=0.001),正常对照组前列腺腺上皮的AR表达明显高于间质(P=0.0001),阳性染色颗粒主要分布在前列腺的腺上皮的细胞核中。早期前列腺癌AR阳性表达率高于晚期(P=0.0227)。高、中分化癌的AR阳性表达率高于低分化癌(P=0.0403)。结论 PCa组织中的AR阳性表达率低于正常前列腺组织。AR的表达与肿瘤的分期、分级相关。
AIM To study the expression of the androgen receptor(AR) in prostalic cancer(PCa) and investigate the relatun between the AR and PCa. METHODS There are 60 samples in Pca group and 40 samples in normal prostate group. The AR in samples were dectected by immunohistochemical SP, RE-SULTS The expression of AR in PCa group was significantly lower than that in controlled group{ P = 0.001) .In normal prostate group, the expression of AR in prostate adenoepithelium was stronger than that in stroma (P = 0.0001). The posilive staining was mainly located in the nuclei of prostate adenoepithelium, AR expression was significant higher in early stage tumors than that in advanced tumors ( P = 0.0227), AR expression was significant higher in well or moder-ately differentiated adenocarcinoma than that in poorly differentiated tumors(P = 0.0403). CONCLUSIONS The positive expression rate of AR in PCa is lower than that in normal prostate. AR expression NS is relative to tumor grades and tumor stages.
出处
《现代泌尿外科杂志》
CAS
2003年第2期98-100,共3页
Journal of Modern Urology
