摘要
目的 探讨交叉反应组 (CREG)配型在高致敏患者肾移植中的临床意义。方法 动态监测肾移植受者体内群体反应性抗体 (PRA)的水平及其特异性 ,按照CREG配型原则选择最匹配的供者。结果 6 0例受者术前PRA超过 11% ,均有单纯性或混合性升高 ;按照CREG配型 ,0～ 1个抗原错配、2个抗原错配、3～ 4个抗原错配者术后肌酐恢复正常的时间平均为 6 .5d、7.0d、12 .7d ,发生肾功能恢复延迟的例数分别为 0、7例、3例 ,各组间的差异具有显著性 (P <0 .0 5 )。结论 高致敏受者在肾移植时采用CREG配型 ,可避开受者预存的HLA抗体特异性所对应的抗原 ,对于提高肾移植人
Objective To investigate the clinical significance of cross reactive groups (CREG) matching in highly sensitized recipients of kidney recipients by testing their serum PRA levels and specificity.Methods The dynamic PRA levels and the specificity were determined. CREG matching was used to select the best donors. Results The preoperative PRA levels in 60 kidney recipients heightened simply or mixedly. Acccording to CREG matching with 0 to 1 MM, 2 MM and 3 to 4 MM, the average recovery time of postoperative creatinine was 6.5 , 7.0 and 12.7 days respectively and the number of the patients with delayed graft function was 0, 7 and 3 respectively.Conclusion There was a great applied value to raise survival rate of patients or allografts for highly sensitized recipients of kidney recipients by CREG matching, to select donors with compatible HLA phenotype or more compatible, to shun the specific antigen of pre existing HLA antibody in recipients and to strictly prohibit HLA repeat mismatches for those retransplantation recipients.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2003年第3期143-144,共2页
Chinese Journal of Organ Transplantation
