摘要
目的 探讨 ER(雌激素受体 )、PR(孕激素受体 )在肺癌组织中的表达情况 ,并分析其与临床病理的关系。方法 应用 S- P免疫组化法检测石蜡包埋的肺癌标本中 ER、PR。结果 ER、PR的阳性表达率分别为 39.5 3%、4 1.86 % ,其中腺癌的表达明显高于其它组织类型。ER、PR的表达与肿瘤细胞分化水平呈正相关 ,而与患者的性别、年龄、临床分期无关。结论 肺癌组织中存在 ER、PR,将其作为激素辅助治疗的一个指标 。
Objective To investigate the correspondence between the expression ofestrogen receptor (ER) and progesterone receptor (PR) in lung cancer. Methods The immunohistochemical way S P was employed to estimate the ER and PR in lung cancer. Results ER and PR positive rates were 39.53% and 41.86%, respectively. Their expression in lung adenocarcinoma was significantly higher than other receptors. There was a significant correlation between ER and PR positive percentage and degree of histological differentiation in lung cancer. The positive percentage was independent from clinical stage, age and sex of the patients. Conclusion It is demonstrated that ER and P are present in lung cancer. This observation may provide a basis for adjuvant hormonal therapy in selected lung cancer patients.
出处
《临床肺科杂志》
2003年第3期192-194,共3页
Journal of Clinical Pulmonary Medicine
