摘要
对56例TAO患者血浆中VEC功能相关指标进行检测,以38例正常人作为对照。结果发现,TAO各辨证组t-PA活性及6-keto-PGF_(1α)。含量下降,vWF水平升高,具有显著性意义(P<0.01)。其中阴寒组和血瘀组PAI活性升高不明显(P>0.05),湿热组以PAI活性显著升高和6-keto-PGF(1α)含量进一步下降为特点,热毒组则以t-PA、PAI活性及6-keto-PGF_(1α)含量的进一步改变为特点。提示:TAO患者存在VEC抗血栓功能改变。
Acute cerebral ischemic-postischemic reperfution injury model in the gerbil was perfomed by ligaturing bilateral carotid arteries for 45 minutes followed by reperfution 45 minutes. The results showed that water and natrium contents in brain tissue markedly increased and microelement cuprum contents droped but kalium, ferrum and zine contents in brain tissue had no change. Injection peritoneal in the model with Bu Yang Huan Wu Tang(equivalent to original drug of 14g/Kg,ip) or tetramethylpyrazine (0. 032g/Kg, ip) 5 minutes before reperfusion, water and natrium contents in brain tissue marked dropped Tetramethylpyrazine might inhibit the decreasion of cuprum in reperfusive brain tissue besides it. The re- sults suggest that the two drugs may resist cerebral ischemic-postischemic reperfution injury by improving water and natrium metablism in brain tissue and the roles of tetramethylpyrazine had bearing on increasing cuprum contets in brain tissue, besides it.
出处
《湖南中医学院学报》
1992年第4期50-52,共3页
Journal of Hunan College of Traditional Chinese Medicine
关键词
血管
内皮细胞
脉管炎
辨证分型
cerebral ischemic-Postischmic reperfution injury
gerbil model
Bu Yang Huan Wu Tang
tetrarnethylpyrazine
therapy
experimental Siudy
