摘要
以 PEG4 0 0 0和十二烷基硫酸钠为载体 ,采用溶剂 -熔融法制备了非诺贝特固体分散体 ,再与适当辅料混合压片制得非诺贝特固体分散片。用正交设计表 L9(34 )筛选处方。溶出度实验表明自制片较市售两种制剂溶出快。
Fenofibrate solid dispersion tablets were prepared by solvent melting method using PEG4000 and sodium lauryl sulfate. The orthogonal design L 9(3 4) was applied in the formulation optimization. The results of dissolution test showed that the dissolution rate of these solid dispersion tablets was more rapid than the other two commercial products.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第5期238-240,共3页
Chinese Journal of Pharmaceuticals
关键词
非诺贝特
固体分散体
溶出度
fenofibrate
solid dispersion
dissolution rate
