摘要
目的 探讨白血病及淋巴瘤患者血清VEGF水平与临床特征的关系。方法 双抗体夹心ELISA法检测初诊 3 9例白血病及 15例非何杰金淋巴瘤 (NHL)患者血清VEGF水平 ,观察其与临床特征的关系。结果 15例NHL患者血清VEGF平均水平为 2 48 93pg/ml( 99～ 72 0pg/ml) ,3 9例白血病患者血清VEGF平均水平为 12 7.5 4pg/ml( 19～ 786pg/ml) ,NHL患者VEGF平均值高于白血病患者平均值 (P <0 .0 0 5 )。 15例NHL中 3例T -NHL患者的VEGF平均值明显高于 12例B -NHL患者的平均值 ( 3 86 67pg/mlvs .189.83pg/ml ,P <0 .0 0 5 )。此 3例T -NHL患者均为高度恶性 ,生存期均较短( 3、4、6月 )。B -NHL中 9例分期≥Ⅲ期的患者血清VEGF平均值为 196 78pg/ml( 12 5～ 3 41pg/ml) ,3例分期 <Ⅲ期患者血清VEGF平均值为 169pg/ml( 99～ 2 41pg/ml) ,两者比较无显著性差异 (P >0 .5 )。 3 9例白血病中 ,急性白血病 (AL)共 2 8例 ,平均血清VEGF水平为 10 9 86pg/ml( 19～ 3 72pg/ml) ,CML及MPD患者共 11例 ,平均血清VEGF为 160 91pg/ml( 5 6～786pg/ml) ,CML及MPD患者的VEGF平均值高于AL患者 ,但经统计学分析 ,差异无显著性 ( 0 1<P <0 .2 5 )。 2 8例AL中 ,19例AML患者的血清VEGF平均值为 12 0 0 5pg/ml( 19～ 3 72pg/ml)较
Objective To measure the serum level of VEGF in patients with leukemia and non-Hodgkin lymphoma and study its clinical significance.Methods The serum levels of VEGF in 39 leukemia and 15 NHL patients were detected by double-antibodies ELISA.Results The average serum VEGF level was 248.93pg/ml(99～720pg/ml)in 15 NHL patients and 127.54pg/ml(19～786pg/ml)in 39 leukemia patients,respectively.The serum VEGF level was higher in NHL patients than in leukemia patients( P <0.005).The average serum VEGF level of 3 T-NHL patients was much higher than that of 12 B-NHL patients(386.67pg/ml Vs.189.83pg/ml, P <0.005).The survival of 3 T-NHL patients with high VEGF level was very short(3m,4m and 6m respectively).The serum VEGF level of B-NHL patients between advanced stage(≥Ⅲ)and early stage(<Ⅲ)had no significant difference(196.78pg/ml Vs.169pg/ml P >0.5).In leukemia group,the serum VEGF level of 28 acute leukemia patients was 109.86pg/ml(19～372pg/ml).Though it was slightly higher in CML/MPD(average 160.91pg/ml,ranging from 56pg/ml to 786pg/ml)there was no significant difference between CML/MPD and AL(0.1< P <0.25).The lowest average VEGF level was 99.67pg/ml(63～181pg/ml)in ALL group.The next was 120.05pg/ml(19～372pg/ml)in 19 AML patients group.Again,there was no difference between ALL and AML.Conclusion The serum VEGF levels in NHL patients are higher than those in leukemia patients.The serum VEGF levels of T-NHL patients are much higher than those of B-NHL patients,and it is found that the higher the VEGF level,the poorer the outcome of treatment.Though it's higher in advanced stage(≥Ⅲ) than in early stage(<Ⅲ),higher in CML/MPD than in AL,and higher in AML than ALL,there are no significant differences between them.
出处
《四川医学》
CAS
2003年第5期443-444,共2页
Sichuan Medical Journal
