摘要
目的 探讨还原型谷胱甘肽 (GSH)治疗多发伤后肝功能损害的疗效评价。方法 多发伤后肝功能损害 10 1例 ,随机分为 2组 ,对照组 49例 ,静脉滴注肌苷 1 0g ,维生素C 2 0g ,门冬氨酸钾镁 2 0mL 1次 /d ,连续用 7d ;治疗组 5 2例 ,在上述治疗的基础上加用GSH 1 2g静脉注射 ,持续 2h停止 ,2次 /d ,连续 2d。同时监测肝功能指标谷丙转氨酶 (ALT)、天冬氨酸转氨酶 (AST)、总胆红素 (TBIL)、总蛋白 (TP)、总胆汁酸 (TBA)、凝血酶原时间 (PT)、部分凝血活酶时间 (APTT)等方面进行比较。结果 GSH治疗组较对照组在多发伤后肝功能复常方面显示良好治疗效应 ,临床症状改善更明显 ,黄疸消退更早 ,显效率分别为 44 % (2 3 / 5 2 )和 2 5 % (12 / 49) ,总有效率分别为 86% (4 5 / 5 2 )和 74% (3 6/ 49) ,两组比较差异有显著性意义 (P <0 0 5 )。
Objective To evaluate the clinical effect of reduced glutathione on the liver dysfunction induced by multiple trauma.Methods 101 patients with liver dysfunction following multiple trauma were randomly divided into 2 groups.The patients received inosine 1.0 g,vitamin C 2.0 g, kali magnesii aspartatis 20 mL every day through intravenous injection for 7 days as the control group(n=49).Besides these treatments,the GSH group(n=52) received GSH 1.2 g per day through intravenous injection for 2h and q12h for 7 days.The clinical and biochemical (ALT,AST,TB,TP,TBA,PT,APTT) parameters were measured.Results ALT,AST,TB showed significant difference in two groups.The GSH in the treatment group (the efficacy rate of 86%) was better significantly than that of the drugs in the control group(the efficacy rate of 74%) (P<0.05).Conclusion GSH had a efficacy in the improvement of clinical signs and hepatic functions in treating the liver dysfunction following multiple trauma.
出处
《中国急救医学》
CAS
CSCD
北大核心
2003年第5期302-303,共2页
Chinese Journal of Critical Care Medicine
