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非编码区三核苷酸重复序列动态突变及相关疾病机制的研究进展 被引量：1

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摘要 三核苷酸重复序列普遍存在于真核生物基因组。三核苷酸重复序列的动态突变与多种人类遗传疾病密切相关。这种动态突变可发生在基因的编码区和非编码区。非编码区三核苷酸动态突变引起的疾病有脆性X综合症 (FragileXsyndrome)、强直性肌营养不良症 (DM )、Friedreich共济失调 (FRDA) ,其遣传不稳定机制为发夹模式和重组修复 (基因转变 )
作者 黄建军
机构地区 中南大学湘雅医学院生化教研室
出处 《国外医学（生理病理科学与临床分册）》 2003年第2期119-121,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 三核苷酸 重复序列 非编码区 突变
分类号 R363 [医药卫生—病理学]
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参考文献22

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同被引文献25

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引证文献1

国外医学（生理病理科学与临床分册）
2003年 第2期

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