摘要
本文着重研究了在混合溶剂中用冠醚作催化剂所进行的Darzens反应,并合成了四个芳族缩水甘油酸酯类化合物.结果表明:采用无水乙醇与石油醚为混合溶剂,以DB-18-C-6作催化剂,能使产率明显提高,产物经元素分析和红外光谱与核磁共振谱鉴定,均与文献报道相符合.此外,还对影响产率的可能机理进行了讨论.
In this paper We mainly studied the catalytic effect of crown ether for Darzens Glycidic Ester Condensation of aromatic aldehydes with ethyl chloroacetate in mixed solvent system . The result showed that the yield of aromatic glycidic ester is 66-87% with DB-18-C-6 as catalyst, anhydrous ethanol and petrleym ethers (b. p. 90-12℃) as solvents and sodium ethoxide as a condensing agent. The possble mechanism was discussed also.
出处
《河南科学》
1992年第1期32-36,共5页
Henan Science
关键词
有机合成
缩合
缩水甘油酸酯
冠醚
Organic synthesis
Condensation
Glycidic Ester
Crown Ether
