摘要
目的 研究经动脉超选择热化疗栓塞治疗肝癌的方法和疗效 .方法 69例肝癌患者随机分为两组 ,实验组 3 9例 ,行经动脉超选择热化疗栓塞 ,将 5 FU、卡铂及丝裂霉素与生理盐水或碘油混合 ,加热至 5 5～ 65℃后经微导管注入肝癌滋养动脉。对照组 3 0例 ,行经动脉超选择化疗栓塞 ,温度控制在 2 0℃。术后记录体温、肝功能变化。观察有无并发症出现。术后每月复查甲胎蛋白 (AFP)及CT ,独立盲法评价碘油沉积情况及肿瘤大小变化 ,并根据病情变化制定后续的治疗方案 ,统计肝癌患者生存率。结果 实验组生存率 :0 .5年、1年、1.5年、2年、3年、4年分别为 ,10 0 %、97%、90 %、79%、62 %、3 8% ,与对照组相比有显著差异 (P <0 .0 5 ) ;肝功能变化与对照组无差异 (P >0 .0 5 ) ;实验组毒副作用与对照组相比无显著性差异。结论 经动脉超选择热化疗栓塞治疗肝癌是较方便、简单、安全的方法 ,能显著提高疗效 ,延长患者生存期。
Purpose To investigate the effectiveness and methodology of superselective transcatheter arterial heated chemoembolization for hepatocellular carcinoma. Methods Sixty nine cases of hepatocellular carcinoma were randomly divided into two groups.Thirty nine cases were treated with superselective transcatheter arterial heated chemoembolization,while 30 cases were treated without heat.In the experimental group,all the 5 fluorouracilum,carboplatinum and mitomycinum C were heated to 55～65℃ with either lipiodol or normal saline before injected into segmental hepatic artery or tumor feeding artery.While in control group,the temperature was controlled at 20℃.Postoperative body temperature and liver function change were recorded.CT and AFP were examined each month.CT film was read independently,according to which follow up treatment was given.Survival rate was recorded. Results In the experimental group,0.5,1,1.5,2,3,4 year survival rate were 100%,97%,90%,79%,62%,38%respectively,significantly higher than those in control group ( P <0.05).No significant difference was found between two groups according to the changes of liver fuction and poisonous side effect. Conclusion Superselective transcatheter arterial heated chemoembolization is a simple,convenient and safe method for treatment of hepatocellular carcinoma,which is more effective in improving the survival rate.
出处
《中国医学影像技术》
CSCD
2003年第4期454-456,共3页
Chinese Journal of Medical Imaging Technology
基金
广东省江门市科委科技攻关项目 (2 0 0 1 81 0 8)
