摘要
脐血移植可以根治白血病、再生障碍性贫血、血红蛋白病及先天性免疫缺陷等疾病 ,尤其适合于儿童患者。临床资料表明同胞脐血移植的效果优于无关供者的脐血移植。对12例白血病或重症再障患儿进行了脐血HLA配型 ,结果配型完全相合4例 ,进行脐血移植3例 ,均成功植活 ,体重最大50kg。可以在胎儿出生时留取脐血配型 ,同时将脐血进行低温保存。提示剖宫产和自然分娩、体内采集脐血和体外采集脐血对脐血的采集体积无明显影响。单份同胞脐血可以重建几乎全部儿童患者的造血功能。对同胞脐血移植的病例 ,主张在分娩时留取脐血进行HLA配型 ,减少产前穿刺对孕妇及胎儿的损伤 ,同时脐血进行冷冻 ,若配型相合再进行脐血移植。
Many hematological diseases such as leukemia,aplastic anemia,hemoglobinophathy and priˉmary immunodeficiency can be treated with umbilical cord blood transplantation especially applicable in children.Clinical data has indicated that sibling umbilical cord blood transplantation is superior to the results from unrelated cord blood transplantation.12children with leukemia or aplastic anemia received HLA ty_ ping.4of them had fully matched silbing donors,with3received sibling cord blood transplantation successˉfully.The highest body weight of the patient transplanted was50kg.The cord blood was collected at the deˉlivery,then small volume of this cord blood was sent to do HLA typing and most of those blood was cryopreˉserved in liquid nitrogen tank at the same time.No significant influence on the cord blood volume collected could be exerted concerning with the collection measures,normal delivery or cesarean section.The hematopoietic function could be reconstructed almost in every child transplanted with the cord blood from a matched sibling,indicating it was worth of recommending to use matched sibling cord blood transplantation in the treatment of children with hematological disorders and primary immunodeficiency because of high success rate and safety.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2003年第4期208-210,共3页
Journal of Clinical Pediatrics
