摘要
目的 研究血清铁、血清铁蛋白与酒精性、非酒精性脂肪肝的关系。方法 采用 1秒钟快速肝穿刺 ,对 97例脂肪肝患者取肝组织标本 ,行HE和铁染色 ,分别用原子吸收光谱法和放射免疫法检测患者的血清铁和血清铁蛋白。结果 中重度酒精性脂肪肝 (AFL)血清铁、血清铁蛋白测定值 [(2 0 .9± 9.3) μmol/L ,(2 17.6± 71.8)ng/ml;(2 9.1± 6 .5 ) μmol/L ,(2 84 .7± 77.9)ng/ml]与对照组 [(10 .5± 5 .7) μmol/L ,(14 3.3± 71.9)ng/ml]比较明显升高 (P <0 .0 1)。重度非酒精性脂肪肝 (NAFL)的血清铁和血清铁蛋白 [(2 1.5± 11.1) μmol/L ,(199.3±72 .1)ng/ml]和对照组 [(10 .5± 5 .7) μmol/L ,(14 3.3± 71.9)ng/ml]比较亦显著升高 (P <0 .0 1) ,而且AFL多出现肝细胞灶性坏死 (6 7% )和肝铁过载(87% )。结论 重度NAFL及中重度AFL多出现血清铁和铁蛋白增高 ,AFL多合并肝铁过载 ,血清铁、铁蛋白可以作为肝铁过载的重要指标。
Objective To study the relationship between serum iron, serum ferritin and alcoholic fatty liver(AFL), nonalcoholic fatty liver(NFAL). Methods The liver specimens of 97 patients with fatty liver were obtained by 1 second liver biopsy, and were further stained by haematoxylin eosin(HE) and Perl's Prussian. Meanwhile the serum levels of iron and ferritin were detected by atomic absorption spectrum and radioimmunoassay respectively. Results Compare to the control group ((10.5±5.7)μmol/L, (143.3±71.9)ng/ml),the serum levels of iron and ferritin were obviously high in patients with severe NAFL ((21.5 ±11.1 ) μmol/L , (199.3±72.1)ng/ml) or moderate AFL((20.9± 9.3 )μmol/L,(217.6.0±71.8)ng/ml) and severe AFL ((29.1±6.5) μmol/L ,(284.7±77.9)ng/ml) ( P <0.01). Focal necrosis(67%) and liver iron overload (87%) were found in many AFL cases. Conclusions In the view of fact that the patients with severe NAFL or with moderate to severe AFL have high serum levels of iron and ferritin. Most of the cases with AFL combined with liver iron overload, thus the serum level of iron and ferritin may be the important marker of liver iron overload.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2003年第4期211-212,共2页
Chinese Journal of Digestion
