摘要
目的 比较不同的促排卵方法联合宫腔内人工授精 (IUI)治疗不孕症的疗效。方法 以 2 0 0 1年 7月～ 2 0 0 2年6月间在我院不孕专科就诊的 195对夫妇作为观察对象 ,分为 3组 :CC/HCG组 ,共 10 3例 ,379个周期 ;CC/FSH/HCG组共 5 8例 ,16 4个周期 ;自然周期对照组 ,共 34例 ,5 5个周期。结果 自然周期对照组的周期妊娠率为 7 3% ,病例妊娠率为 11 8%。CC/HCG组的周期妊娠率为 12 0 % ,与对照组相比没有显著性差异 (P >0 0 5 ) ,与CC/FSH/HCG组相比有显著性差异 (P <0 0 1) ;病例妊娠率为 34 6 % ,与对照组相比有显著性差异 (P <0 0 1) ,与CC/FSH/HCG组相比有显著性差异 (P <0 0 5 )。CC/FSH/HCG组周期妊娠率为 2 2 6 % ,与对照组相比有显著性差异 (P <0 0 5 ) ;病例妊娠率为 6 0 3% ,与对照组相比也有显著性差异 (P <0 0 1)。结论 采用CC/HCG或CC/FSH/HCG促排卵可提高IUI治疗不孕症的妊娠率。
Objective:To compare curative effect of different methods of superovulation in combination with intrauterine insemination for treatment of infertility.Methods:Between July 2001 and June 2002,195 infertile couples were divided into three groups.Group 1(n=103,treated cycles=379) were treated with clomiphene citrate(CC)/human chorionic gonadotropin(HCG)in combination with IUI.Group 2(n=58,treated cycles=164) had undergone clomiphene citrate(CC)/follicle-stimulating hormone(FSH)/human chorionic gonadotropin(HCG) plus IUI.Group 3(n=34,treated cycles=55)was natural cycle contrast group including unstimulated cycles plus IUI.Results:42 pregnancies developed in group 1.The pregnancy rate was 12.0% and the pregnancy rate per cycle 34.6%. 35 pregnancies occurred in group 2.The pregnancy rate was 22.6% and the pregnancy rate per cycle 60.3%.4 pregnancies developed in group 3.The pregnancy rate was 7.3% and the pregnancy rate per cycle 11.8%.Pregnancy rate per cycle in group 1 was significantly higher than that in group 2(P<0.01)and no significantly higher than that in group 3(P>0.05).Pregnancy rate per couple in group 1 was significantly higher than those in group 2(P<0.01)and in group 3(P<0.01).There were significant differencies in pregnancy rate per cycle and per couple between group 2 and group 3(respectively P<0.05,P<0.01).Conclusion:Among infertile couples,treatment with induction of superovulation and intrauterine insemination can result in higher pregnancy rate than intrauterine insemination alone.
出处
《中国优生与遗传杂志》
2003年第2期93-94,49,共3页
Chinese Journal of Birth Health & Heredity
