摘要
分析遗传性非息肉病性大肠癌(HNPCC)的临床特点。方法:对10个家族27例HNPCC患者(A组)进行回顾性分析,并设30例一般大肠癌为对照组(B组)进行比较。结果:<50岁患者A组占59.3%(16/27),B组占23.3%(7/30),P<0.05。脾曲以上癌灶A组为40.0%(12/30),B组为16.1%(5/31),P<0.05。大肠多原发癌A组占10.0%(3/30),B组占3.2%(1/31)。大肠外肿瘤A组6例,B组2例。结论:HNPCC具有典型的临床特征,这些特征可以对HNPCC患者进行早期诊断及治疗,以得到较好的预后。
Objective:To analyse the clinical features of hereditary nonpolyposis colorectal cancer(HNPCC).Methods:A retrospective analysis of27HNPCC cases in10families(group A)was made and compare with30general colorectal cancer cases(group B).Results:Patients under the age of50were significantly higher in group A59.3%(16/27)than in group B23.3%(7/30)P<0.05.The tumors were found perximally to splenic flexure colon40%(12/30)in group A and16.1%(5/31)in group B P<0.05.Multiple primary colorectal cancer had10%(3/30)in group A and3.2%(1/31)in group B.Pafients who suffered from cancer in other organs had6cases in group A and2cases in group B.Conclusion:HNPCC has typical clinical features,ac-cording to these features,We can make the diagnosis and treatment at the ealy stage and get a better prognosis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2003年第4期247-249,共3页
Chinese Journal of Clinical Oncology
