摘要
目的 通过金黄色葡萄球菌对小鼠致病性的实验研究 ,探讨该菌的致病机理。方法 用金黄色葡萄球菌标准株 (SA180 0 )和鼠源性分离株 (SA .m0 10 9)攻击小鼠 ,造成小鼠金黄色葡萄球菌感染模型 ,观察其病变特点 ,并进行检测 ,确定感染率与毒力。结果 SA180 0和SA .m0 10 9均能造成小鼠发病 ,其中SA .m0 10 9致病性较强。SA180 0对小鼠的半数致死量 (LD50 )为 10 - 4 1 / 0 2ml;SA .m0 10 9对小鼠的半数致死量 (LD50 )为 10 - 5 1 / 0 2ml。结论 为金黄色葡萄球菌的致病机理和疫苗研究提供了良好的动物模型。
Objective To study the mechanisms of pathogenicity of %Staphylococcus aureus%(SA). Methods Experimental strains of %S.aureus% were SA1800 and SAm0109. After inoculating with the bacteria, the clinical symptoms and pathogenic changes of experimental mice were examined. Results Obvious invasion of the bacteria was found. The LD 50 of SA1800 to experimental mice was 10 -4.1/0.2 ml, and the LD 50 of SAm0109 to experimental mice was 10 -5.1/0.2 ml. Conclusion It was a good animal model for studying the pathological mechanisms of %S.aureus% and the development of its vaccine.;
出处
《中国比较医学杂志》
CAS
2003年第2期87-89,共3页
Chinese Journal of Comparative Medicine
基金
国家"十五"科技攻关计划"国家遗传工程小鼠资源库的建立"(项目编号 :2 0 0 1BA70 113)。
