1[1]Zhang Y, Proenca R, Ma-frei M, et al. Positional cloning of the mouse obese gene and its human homologue [ J ]. Nature, 1994,372 ( 12 ): 425-432.
2[2]Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene[ J ]. Science, 1995,269 ( 7 ):543-546.
3[3]Emilsson V, Liu YL, Cawthorne MA, et al. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secrection[ J]. Diabetes, 1997,46(2): 313-316.
4[4]Kieffer TJ,Heller RS,Leech CA, et al. Leptin suppression of insulin secretion by the activation of ATP-sensitive K channels in pancreatic B-cells[ J] . Diabetes, 1997,46(6): 1087-1093.
5[5]Lupi R, Marchetti P, Maffei M, et al. Effects of acute or prolonged exposure to human leptin on isolated human islet function[J]. Biochem Biophys Res Commun, 1999,256(2): 637-641.
6[6]Chen NG, Swick AG, Romsos DR. Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice[J]. J Clin Invest, 1997,100(5): 1174-1179.
7[7]Ookuma M,Ookuma K,York DA.Effect of leptin on insulin secrection from isolated rat pancreatic islets [J]. Diabetes, 1998,47 ( 2 ): 219 -223.
8[8]Seufert J, Kieffer TJ, Habener JF. Leptin inhibits insulin gene transcription and reverses hyperinsulinaemia in leptin-deficient ob/ob mice[J].Proc Natl Acad Sci USA, 1999,96(3):674-679.
10[10]Rossetti L, Massillon D, Barzilai N, et al. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action[J]. J Biol Chem,1997,272(11): 27758-27763.
