摘要
目的 分析连续肾替代治疗 (continuousrenalreplacementtherapy,CRRT)对严重烧伤脓毒症患者血浆内毒素和细胞因子水平的影响。 方法 对 10例应用CRRT及 10例应用常规疗法治疗的严重烧伤脓毒症患者血浆内毒素和细胞因子 (TNFα、IL 1β、IL 6、IL 8)浓度变化进行比较分析。 结果 严重烧伤脓毒症患者应用CRRT后血浆内毒素、细胞因子浓度较治疗前明显下降 ,其下降速度与常规治疗组比较差异有非常显著性意义 (P <0 .0 1)。
Objective To investigate the influence of continuous renal replacement therapy (CRRT) on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis. Methods Ten burn patients who received CRRT and another 10 without CRRT were investigated in terms of the changes in their plasma concentrations of endotoxin and some cytokines (TNFα, IL 1β, IL 6, IL 8). Results The plasma concentrations of endotoxin and all the cytokines (TNFα, IL 1β, IL 6, IL 8) after CRRT treatment were significantly lower than those before the treatment (P<0.01), and the plasma levels of the above factors at all the time points after CRRT treatment than those in patients were evidently lower by routine treatment (P<0.05 0.01). Conclusion CRRT treatment could effectively lower the plasma levels of endotoxin and some cytokines (TNFα, IL 1β, IL 6, IL 8).
出处
《中华烧伤杂志》
CAS
CSCD
2003年第2期67-70,共4页
Chinese Journal of Burns
基金
全军医药卫生科研基金课题 ( 0 1L0 66)
