摘要
目的 :探讨膀胱移行细胞癌患者血液中血管内皮生长因子 (VEGF)的表达及意义。方法 :采用双抗体夹心ELISA法对 42例膀胱移行细胞癌患者及 10例正常人血液中VEGF的检测 ,研究膀胱移行细胞癌患者在化疗或手术前、后血液中VEGF的表达 ,以及不同瘤级和不同浸润深度患者血液中VEGF的表达。结果 :在术前、吡柔比星灌注化疗后、肿瘤切除后 5 - 7d ,病人血液中VEGF值明显高于正常人 ;在化疗或手术后 ,患者血液中VEGF的水平明显下降。随着瘤级的升高或浸润深度的增加 ,患者血液中VEGF的水平也增高。结论 :检测膀胱癌患者血液中的VEGF的水平 ,监测它的变化 ,对预测肿瘤恶性潜能、以及了解肿瘤的治疗效果和肿瘤的发展情况 ,有重要的临床意义。
AIM: To investigate serum vascular endothelial growth factor (VEGF) level in patients with bladder transitional cell carcinoma(BTCC) and its clinical significance. METHODS: ELISA method was used to examine the serum VEGF level in 42 cases of bladder transitional cell carcinoma and in 10 cases of normal people as control. The change of VEGF in blood of the pre-operation and post-operation patients with BTCC was also compared. RESULTS: The VEGF level in blood of the patients was higher than that of the normal people, in spite of pre-operation, post-chemotherapy, and post-operation, but VEGF level decreased obviously after chemotherapy or operation. In addition, the plasma VEGF level was related to the grade and invasion of tumor. CONCLUSION: Detecting serum VEGF level can help us to assess the change of tumor and therapeutic effect.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2003年第4期526-528,共3页
Chinese Journal of Pathophysiology
