摘要
目的:探讨Na+/H+交换阻滞剂Cariporide对离体大鼠心肌梗死范围的影响。方法:用离体大鼠双冠脉分别灌流心肌缺血模型,将大鼠心脏进行45 min的低流量缺血(用原灌流量的5％进行灌流),再灌注2h。药物在缺血及再灌注的不同时期应用。结果:在缺血及再灌注时和缺血再灌注时联合应用1μmol/L Cariporide,心肌梗死范围分别是(7±1)％,(7±2)％,(2±1)％,较对照组(20±4)％明显缩小。在缺血后0,10,30 min时分别应用,其心肌梗死范围分别是(7±2)％,(10±1)％,(17±3)％,较对照组(22±3)％明显缩小。在再灌注0,10 min时分别应用,其心肌梗死范围分别是(6±2)％,(15±2)％,而对照组为(19±3)％。结论:Na+/H+交换阻滞剂Caripo-ride在缺血及再灌注早期应用有明显的缩小心肌梗死范围作用。
Objective: We tried to test the effect of Ma+/ H+ exchange inhibitor Cariporide on size of myocardial infarction in isolated rat hearts. Methods: We set up models of isolated double coronary arteries perfusion in rats. The hearts underwent low-flow ischemia for 45 minutes (flow to the left coronary bed was reduced to 5% of base values using dual perfusion technique) and 2-hour reperfusion. The medicine were given to the hearts in different periods during ische-mia-reperfusion. Results: The sizes of myocardial infarction in hearts, to which 1 μmol/L Cariporide had been infused during ischmia, during reperfusion, and during ischemia-reperfusion, were (7 ±1 )% , (7 ±2)% , and (2 ± 1 )% , respectively. That was much less than that of control group, which was (20±4)%. When Cariporide was given 0, 10, and 30minutes after ischemia, the sizes of myocardial infarction were (7±2 ) % , (10±1)%, and ( 17 ± 3 ) % , respectively. That was also less than that of control group, which was (22±3) %. Cariporide was ineffective when it was used 30 minutes after ischemia or 10 minutes after reperfusion. When Cariporide was administrated 0 and 10 minutes after reperfusion, the sizes of myocardial infarction were (6±2)% and (15±2)% while that of control group was (19±3)%. Conclusion : The Na +/H+ exchange inhibitor Cariporide could reduce size of myocardial infarction obviously when it was administrated during early period of ischemia and reperfusion.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2003年第2期120-122,共3页
Journal of China Medical University
