摘要
以丙酮为溶剂进行同位素交换反应制备^(131)I-碘化油,操作简便,标记率可达95％以上。室温放置15d及高压灭菌后未见脱碘现象。γ照相显示^(131)I-碘化油注入狗的肝动脉后,仅选择性地蓄积于注入动脉的供血区内,甲状腺及肺等其它部位未见核素蓄积。^(131)I-碘化油在肝内的有效半衰期为4.92±0.66d。每毫升血液放射性仅为注入量的0.09±0.04％,提示^(131)I-碘化油性能稳定,适宜临床应用。
Lipiodol was labelled with 131I using an iodine exchange reaction with acetone as solvent. The labelling rate was 95%. No dehalogenation was detected within 15 days at room temperature or after sterilization. Animal experiments showed that after hepatic arterial injection 131I -lipiodol was selectively accumulated in the embolized local area. No increased activity was observed in the thyroid, lung or other areas. The effective half - life in liver was 4. 92±0. 66 days. The blood radioactivity per ml was 0. 09±0. 04% of the injected dose . The results suggest that the 131I - lipiodol is very stable and suitable for clinical application.
出处
《核技术》
CAS
CSCD
北大核心
1992年第11期661-664,共4页
Nuclear Techniques
关键词
碘化油
肝癌
栓塞
碘131
131I-lipiodol Labelled rate Animal experiment
