摘要
电损伤可造成大鼠拟痴呆动物模型。用受体放射性配基结合分析法,观察到:大鼠大脑皮层、海马和小脑组织中α_1受体的B_(max)值显著降低,调理心肾中药和对照西药喜德镇(Hydergin)均可明显提高拟痴呆动物脑组织中α_1受体的B_(max)值,使接近正常对照组。电损伤没有引起大鼠脑组织中的MAO-B活性升高,调理心肾中药和西药对MAO-B活性亦无明显调节作用。
Analogue dementia modelof rats was produced by electrolytic lesion of brain. α1 -adrenergic receptors were assayed by radioligand binding assay (RRBA). It was found that Bmax of α1 receptors was decreased obviously in cerebral certex, hippo- campus and cerebellum of analogue dementia rats and was raised obviously by Heart-and Kidney- Benefiting Chinese Herbs as well as by Hydergin.The electrolytic lesion did not change the activity of MAO-B in model rat brains. Neither Heart- and Kidney- Benefiting Chinese Herb Medicines nor Hydergin showed marked effect on brain MAO-B activity of the model rats.
出处
《核技术》
CAS
CSCD
北大核心
1992年第5期304-308,共5页
Nuclear Techniques
关键词
肾上腺能受体
神经递质
Heart- and kidney- benefiting Chinese herb medicines Analogue dementia rats Monoamine oxidase-B (MAO-B) Adrenergic receptor Neurotransmitter
