摘要
侵袭性肺曲霉病诊断困难 ,病情凶险 ,死亡率高。本文对合并有侵袭性肺曲霉病的 3例恶性血液病 (2例急性白血病和 1例MDS RA)患者的诊治过程进行了回顾性分析。 3例患者均有免疫力低下的病史 ,虽经过预防性抗真菌治疗 ,仍发生了肺曲霉菌感染 ,经过痰培养确诊后采用脂质体两性霉素B ,伊曲康唑和氟胞嘧啶联合治疗。结果表明 ,联合治疗 7- 14天后 ,3例中 2例痊愈 ,1例显效。结论 :对侵袭性肺曲霉病的早期诊治很关键 ,脂质体两性霉素B ,伊曲康唑和氟胞嘧啶联合治疗起效快 。
Invasive pulmonary aspergillosis is difficult to diagnose and a critcal ill with high mortality. In this paper, the diagnosis and treatment of invasive pulmonary aspergillosis complicated in 3 cases of hematological malignancy (2 acute leukemias and 1 MDS RA) were retrospectively analysed. All patients had histories of hypoimmunity and were received prophylactic antifungal treatment. Pulmonary aspergillosis infection still occured and confirmedly diagnosed by sputum examination. After 7 to 14 days of combination treatment of liposomal amphotericin B, itraconazole and flucytosine, 2 cases were cured and another showed effective. In conclusion, early dignosis and treatment of invasive pulmonary aspergillosis are very critical and the therapeutic effectiveness of combined scheme with liposomal amphotericin B, itraconazole and flucytosine is very effective for pulmonary aspergillosis.
出处
《中国实验血液学杂志》
CAS
CSCD
2003年第2期202-204,共3页
Journal of Experimental Hematology
