摘要
目的探讨C 反应蛋白 (CRP)、基质金属蛋白酶 2 (MMP 2 )在急性冠脉综合征 (ACS)患者血清中的变化及其相关性。方法分别应用ELISA法及散射比浊法对 5 2例ACS患者及 2 0例正常人外周血血清中CRP、MMP 2水平进行测定。结果ACS组CRP、MMP 2水平明显高于对照组 (P <0 .0 1) ,AMI组与UA组CRP、MMP 2水平有显著性差异(P <0 .0 1)。经Logistic回归分析显示 ,CRP、MMP 2的风险比值 (0R)均大于 1,是ACS的危险因素。经Forward法观察CRP、MMP 2在ACS中的作用是相互独立的。结论ACS患者CRP、MMP 2水平升高 ,二者是ACS发生、发展的独立危险因素。
Objective To study the changes of C-reactive protein(CRP) and matrix metalloproteinase-2(MMP-2) level in acute coronary syndrome(ACS) and their correlation. Methods The levels of CRP and MMP-2 in peripheral serum of 52 ACS patients and 20 normal control were measured,respectively,by ELISA and scatter rate turbidity. Results The levels of CRP and MMP-2 in ACS group were higher than that in control group(P<0.01).There was significant difference in CRP and MMP-2 between AMI subgroup and UA subgroup(P<0.01). Logistic regression analysis showed that the odds ratio(OR) of both CRP and MMP-2 was >1, indicating that CRP and MMP-2 were risk factors. CRP and MMP-2 were independent in the course of ACS. Conclusion CRP and MMP-2 levels are increased, which are the independent risk factors in incidence and development.
出处
《中国综合临床》
北大核心
2003年第5期403-404,共2页
Clinical Medicine of China
