摘要
Objective: To investigate phospho-b-catenin expression in non-small cell lung cancer (NSCLC) and to study the relationship between phospho-b-catenin expression and some clinical pathological factors. Methods: The expression of phospho-b-catenin in 67 primary NSCLC cases detected immunohistochemically. Results: phospho- b-catenin was not expressed in normal bronchial mucous cell and showed cytoplasmic and nuclear expression in NSCLC cell. Total positive expression rate reached 62.7%, and positive expression rate of nucleus was 38.8%. The positive expression rate (87.5%) and nuclear expression rate of adenocarcinoma (62.5%) were apparently higher than those of squamous cell cancer (40.0% and 17.1%) (P<0.01). Expression of phospho-b-catenin had no relationship to differentiation degree and lymphatic metastasis. The postoperative survival time is not related to phospho-b- catenin expression. (Log-rank test, P=0.9198; P=0.6274). COX model analysis showed that tumor stage and differentiation are independent risk factors to prognosis (P=0.001; P=0.020). Conclusion: NSCLC cells show positive expression of phospho-b-catenin, phospho-b-catenin nuclear expression is relevant to histological types. There is no difference in postoperative survival time between patients with phospho-b-catenin positive expression and patients with negative expression, expression of phospho-b- catenin is not independent risk factor to prognosis.
Objective: To investigate phospho-b-catenin expression in non-small cell lung cancer (NSCLC) and to study the relationship between phospho-b-catenin expression and some clinical pathological factors. Methods: The expression of phospho-b-catenin in 67 primary NSCLC cases detected immunohistochemically. Results: phospho- b-catenin was not expressed in normal bronchial mucous cell and showed cytoplasmic and nuclear expression in NSCLC cell. Total positive expression rate reached 62.7%, and positive expression rate of nucleus was 38.8%. The positive expression rate (87.5%) and nuclear expression rate of adenocarcinoma (62.5%) were apparently higher than those of squamous cell cancer (40.0% and 17.1%) (P<0.01). Expression of phospho-b-catenin had no relationship to differentiation degree and lymphatic metastasis. The postoperative survival time is not related to phospho-b- catenin expression. (Log-rank test, P=0.9198; P=0.6274). COX model analysis showed that tumor stage and differentiation are independent risk factors to prognosis (P=0.001; P=0.020). Conclusion: NSCLC cells show positive expression of phospho-b-catenin, phospho-b-catenin nuclear expression is relevant to histological types. There is no difference in postoperative survival time between patients with phospho-b-catenin positive expression and patients with negative expression, expression of phospho-b- catenin is not independent risk factor to prognosis.
基金
This work was supported by the grants for studied abroad and returned scholars from Ministry of Education of China (No. 2002-247). *
