摘要
本实验基于肺气肿的产生主要是由于肺内弹性蛋白酶及其抑制因子平衡失调的学说,采用气溶胶雾化吸入法成功地制造了豚鼠肺气肿动物模型,并筛选出8种中草药制成宣肺清水剂(简称宣肺清).用同样雾化吸入法对豚鼠肺气肿进行了防治研究。结果证实:宣肺清对防治肺气肿具有显著疗效。为探讨肺气肿的发生机制和肺气肿的防治提供了实验依据。
Pneumonectasis was induced by means of aerosol inhalation in guinea-pig, the experiment was based upon a theory, it expounded that pneumonectasis results mainly from disequilibrium of pulmonary elastic protease and its inhibitor. Simultaneously, 8 sorts of chinese herbal medicine were effectively chosen and prepared the hydrated preparation of Xuan Fei Qing. The study on prevention and cure of pneumonectasis in guinea-pig was carried out with Xuan Fei Qing by the same method. The results demonstrate that Xuan Fei Qing owns remarkable effect on prophylaxis and treatment of the pulmonary disease and can confirm further the theory mentioned above. Moreover, the establishment of pneumonectasis model plays an important role in researching its pathogenesis and prevention and cure.
出处
《哈尔滨医科大学学报》
CAS
1992年第1期10-13,78,共5页
Journal of Harbin Medical University
关键词
肺气肿
弹性蛋白酶
动物模型
病理
Pneumonectasis
Elastic protease and its inhibitor
Animal model
Prevention and cure of pneumonectasis
