摘要
目的 观察肠易激综合征 (IBS)患者的胃窦十二指肠移行性复合波 (MMC)变化 ,并分析其与症状之间的关系。方法 2 0名健康对照者及 17例IBS患者 (8例腹泻型 ,9例便秘型 )禁食 6h以上 ,用瑞典CTD公司生产的灌注式小肠测压管记录至少 2个完整的MMC周期 ,之后给每位受试者服标准餐 ,用餐时间为 15～ 30min ,继续观察餐后波 1～ 2h。结果 腹泻型IBS患者消化间期MMC周期短、Ⅲ相波幅高、时程长 ,便秘型IBS患者MMC周期长、时程短。IBS患者MMCⅡ相小肠离散丛集簇(DCC)波的时程延长 ,但腹泻组与便秘组之间差异无显著性 (P >0 .0 5 )。IBS腹泻组的Ⅱ、Ⅲ相的运动指数高于便秘组和对照组。进餐后IBS患者小肠运动形式无明显改变。结论 IBS患者消化间期MMC的各相时程及波幅异常与IBS症状密切相关 ,DCC可能与IBS腹泻、便秘症状发生的关系较小 ,IBS患者餐后胃肠运动无明显异常 ,可能与病例数较少有关 。
Objective To investigate the variety of antro duodenal motility in patients with diarrhea or constipation predominant irritable bowel syndrome (IBS) and to elucidate the pathophysiology of IBS. Methods After 6 hours fasting, 17 patients with IBS (diagnosed by Rome Ⅱ criteria), 8 with diarrhea predominant diarrhea(D IBS) and 9 with constipation predominant IBS(C IBS), were investigated by gastrointestinal manometry (STD Co., Sweden) for recording at least 2 intergrated interdigestive migrating motor complex (MMC) cycles and observing 2 hours of postprandial antro duodenal motility. Results The MMC periods was shorter, phase Ⅲ duration was longer and amplitude was higher in D IBS group than in controls, whereas the MMC periods was longer and the phase Ⅲ duration was shorter in C IBS group than in controls. The duration of discrete clustered contraction(DCC) in phase Ⅱ was longer in IBS groups than in health controls, but there was no significant difference between the C IBS group and the D IBS group. The motility index in late phase Ⅱ and phase Ⅲ was higher in IBS D group, but for the IBS C group the motility index had no statistical difference from that for controls. The postprandial motility pattern of duodenum had no remarkable difference between IBS patients and controls. Conclusions The gastrointestinal motility disorders are apparent in the IBS patients. There is close relation between gastrointestinal motility disorders and the symptoms of the IBS patients. DCCs waves may almost be independent of constipation or diarrhea of IBS.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2003年第3期142-145,共4页
Chinese Journal of Digestion
