摘要
目的:探讨5-氟尿嘧啶在青光眼复合式小梁切除术后的应用及疗效。方法:将28例(35只眼)青光眼患者(55岁以下)随机分成A、B两组:A组(18只眼),术后应用5-氟尿嘧啶;B组(17只眼),术后不应用5-氟尿嘧啶。对A、B两组患眼均施行复合式小梁切除术,观察术后7、14天,1、3、6个月的眼压、前房深浅及滤枕情况。结果:(1)眼压:两组患者术前、术后7天的眼压差异无显著性;术后14天,1、3、6个月的眼压差异有显著性。(2)前房深浅:术后7天内均有不同程度浅前房发生,术后7～14天前房无明显变化(介于I～Ⅱ级之间),术后1、3、6个月前房无明显变化(I级以下)。(3)滤枕情况:A组滤枕均扁平弥散,B组于术后14天后有1例滤枕明显局限,1个月后14例滤枕明显局限,3个月后16例滤枕明显局限,6个月后16例滤枕明显局限。结论:术后应用5-氟尿嘧啶能有效抑制瘢痕形成,使滤过通畅,达到滤过手术的良好效果。但对远期效果有待进一步随访观察。
Objective:To study the application and treatment effect of fluorouracil(5 - Fu) after the filtering surgery of glaucoma. Methods:28 patients(35 eyes)of glaucoma were divided into two groups, group A and group B. Group A( 18 eyes) was applied with 5 - Fu after operation and group B wasn' t done with 5 - Fu after operation. Both groups were performed with the same operation. We compared the postoperative intraocular pressure(IOP), the deepness of anterior chamber and the situation of filtering bleb at different time. Results: (1) IOP: Statistically, significant differences between the two groups were found on the postoperative 14. 30,90 and 180 days, however, significant difference was not noted between them on the pre - operation and postoperative 7 days. (2)Deepness of anterior chamber: Shallow anterior chamber of different degrees in all patients took place within the postoperative 7 days. The situation of anterior chamber had no obvious difference between the postoperative 7 days and 14 days(between degree I and II), and the difference was not significant on the postoperative 30. 90 and 180 days(below degree I ). (3)The situation of filtering blebs:All of the filtering blebs in group A were flat and diffuse,but the filtering blebs in group B were: 1 eye had an obviously limited bleb on the postoperative 14 days, 14 eyes did on the 30 days, 16 eyes did on the 90 days and 16 eyes did on the 180 days. Conclusion: The application of 5-Fu after operation can effectively inhibit the tissue cicatrizotion, which makes the humor equeous filtering freely and plays a vital role in treatment effect,but its late result remains to be further followed up and observed.
出处
《现代医药卫生》
2003年第4期385-386,共2页
Journal of Modern Medicine & Health
