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低温停循环选择性脑灌注应用于胸主动脉瘤的手术治疗 被引量:1

Surgical treatment of thoracic aortic aneurysm with hypothermic circulatory arrest and antegrade selective cerebral perfusion
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摘要 目的 :总结右锁骨下动脉插管、中度低温停循环 (HCA)、顺行选择性脑灌注 (ASCP)行胸主动脉瘤手术治疗的经验。方法 :11例患者中 ,男 10例 ,女 1例 ,夹层动脉瘤 10例 (慢性DeBakeyI型 5例 ,Ⅱ型 4例 ,急性Ⅱ加Ⅲ型 1例 ) ,升主动脉瘤加降主动脉缩窄 1例 ,均并发主动脉瓣中重度反流。术中采用右锁骨下动脉 右房插管 ,建立体外循环后并行降温至 30℃ ,阻断升主动脉 ,处理近端并继续降温至 2 3℃ ,阻断无名动脉 ,转为HCA加ASCP处理远端。 10例行Bentall术 ,1例行Bentall加升主动脉 降主动脉搭桥术。平均体外循环时间 (112 .3±37.9)min ,HCA加ASCP时间 (2 5 .4± 8.8)min。结果 :所有患者均于术后 4~ 6h清醒 ,无死亡及脑部并发症。结论 :以右锁骨下动脉插管建立体外循环、HCA加ASCP ,操作简便易行 ,可安全地延长停循环时限及有效防止脑部并发症 。 Objective:We review our clinical experience of surgical treatment of thoracic aortic aneurysm using right subclavian artery cannulation, moderate hypothermic circulatory arrest and antegrade selective cerebral perfusion.Methods:A total of 11 consecutive thoracic aortic aneurysm patients (mean age 51 years, range 22 to 65 years) concomitant moderate to severe aortic valvular regurgitation were studied. One of them was ascending aortic aneurysm with coarctation of descending aorta; and the other 10 cases were aortic dissections (chronic De Bakey type I 5 cases, type II 4 cases and acute type II+III 1 case). Extracorporeal circulation was established with right subclavian artery and right atrium cannulation. After the patient was cooled down to 30℃ with partial bypass, ascending aorta was cross clamped and the proximal part of the composite valve graft was sewn to aortic annulus with a continuous suture. When the body temperature was lowered to 23℃, innominate artery and left common carotid artery were clamped. While systemic circulatory was arrest, the antegrade selective cerebral perfusion was started at rate of 10 ml·min -1 ·kg -1 and the appropriate procedure was performed on distal ascending aorta. Eight patients received Bentall procedure while one underwent Bentall procedure and ascending aorta to descending aorta bypass. Mean extracorporeal circulation time was ( 112.3 ± 37.9 ) min and mean antegrade selective cerebral perfusion time was ( 25.4 ± 8.8 )min.Results:All patients recovered from anesthesia between 4 to 6 hours after operation. There were no death and no cerebral morbidity.Conclusion:Right subclavian artery cannulation with hypothermic circulatory arrest and antegrade selective cerebral perfusion allows increased ease of surgical performance and prolonged safe time limit of circulatory arrest and helps reduce cerebral morbidity, may lead to improved outcomes.
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2003年第3期155-157,共3页 Journal of Clinical Cardiology
关键词 胸主动脉瘤 低温停循环 顺行选择性脑灌注 血管外科手术 治疗 Thoracic aortic aneurysm Hypothermic circulatory arrest Antegrade selective cerebral perfusion Vascular surgery
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参考文献5

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同被引文献7

  • 1Chong S, Chow M, Kang D,et al. Deep hypothermic circulatory arrest in adults undergoing aortic surgery: local experience [J] . Cardiowasc Surg, 2003,6(4) :398 -405.
  • 2Czemy M, Fleck T, Zimpfer D, et al. Risk factors of mortality and permanent neurologic injury in patients undergoing ascending aortic and arch repair[J]. J Thorac Cardiovasc Surg, 2003, 126(5): 1296-301.
  • 3Chong SY, Chow MY, Kang DS, et al. Deep hypothermic circulatory arrest in acult undergoing aortic surgery: local experience [J]. Ann Acad Med Singapore, 2004,33(3) :289 - 293.
  • 4Coselli JS, LeMaire SA. Experoemce with retrograde cerebral perfusion during proximal aortic surgery in 290 patients [J]. J Catd Surg, 1997,12(2 Suppl) :322 - 325.
  • 5Pasic M, Schubel J, Bauer M, et al. Canulation of the right axillary artery for surgery of acute type A aortic direction [J]. Eur J Cardiothorac Surg, 2003 ,24(2) :231 - 236.
  • 6Piccioni MA, Leimer AA, Anler JO Jr. Comparison of pH-stat versus Alpha-stat during hypothermic cardiopulmonary bypass in the prevention and control of acidosis in cardiac surgery[J]. Artif Or gans,2004,28(4) :347 - 352.
  • 7杨苏民,徐平,曹倩.深低温、停循环、经右锁骨下动脉脑灌注在主动脉弓重建术中的应用(附11例报告)[J].山东医药,2003,43(6):1-3. 被引量:1

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