摘要
目的 检测植入骨基质明胶 (BMG)后转化生长因子 - β1(TGF - β1)的含量 ,以此评价BMG的生物活性及抗原性。 方法 BMG组 2 0例 ,为骨折愈合障碍病例 ;对照组 2 0例为新鲜骨折病例 ,两组均行内固定术 ,并于术前、术后 1周、术后 2周检测血清TGF - β1。 结果 (1)BMG组术后 1,2周 [TGF - β1分别为 (10 4.489± 16.0 7)ng ml、(113 .40 6± 2 3 .70 6)ng ml]与术前 [(92 .897±16.13 5 )ng ml]比较 ,差异有非常显著性意义 (P <0 .0 1) ,术后 2周与术后 1周比较 ,差异有显著性意义 (P <0 .0 5 ) ;(2 )对照组术前 [TGF - β1为 (110 .472± 19.72 3 )ng ml]与术后 [(114.679± 2 0 .3 5 8)ng ml、(116.42 3± 2 4.10 9)ng ml]比较 ,差异无显著性意义 (P >0 .0 5 ) ;(3 )BMG组与对照组术前比较 ,差异有显著性意义 (P <0 .0 5 )。 结论 BMG植入后表现出明显的成骨活性 。
Objective To detect the changes of transforming growth factor beta 1 (TGF β1) following implantation of bone matrix gelatin (BMG) and evaluate biological activity and antigen of BMG. Methods Twenty cases with disturbance of bone union were used as Group BMG and 20 cases with fresh fracture as control group. Internal fixation was done in both groups. TGF β1 was detected 1 week before operation, 1 week and 2 weeks after operation respectively. Results (1) TGF β1 in the Group BMG showed very significant difference postoperatively compared with preoperation ( P <0.01),and significant difference at the second postoperative week compared with the first postoperative week ( P <0.05). (2) There was insignificant difference in the control group preoperatively and postoperatively ( P >0.05). (3) In Group BMG, significant difference was found compared with control group preoperatively ( P <0.05). Conclusions Implantation of BMG show remarkable activity of bone formation without immunoreaction.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2003年第3期170-171,共2页
Chinese Journal of Trauma
基金
国家自然科学基金资助项目 (39860 0 75 )
关键词
骨基质明胶
转化生长因子-Β1
骨折固定术
抗原性
Gelatin, bone matrix
Transforming growth factor beta 1
Fracture fixation, internal
Antigen
