摘要
目的 探讨乌司他丁对溃疡性结肠炎 (UC)的治疗效果及其作用机制。方法 40只成年Wistar鼠 ,随机分为四组 ,正常组 (A组 )、溃疡性结肠炎组 (B组 )、柳氮磺胺吡啶 (SASP)治疗组 (C组 )、乌司他丁治疗组 (D组 ) ,用三硝基苯磺酸 (TNBS)诱导实验性UC的大鼠模型 ,A、B二组用生理盐水处理大鼠。用药治疗 2周后 ,分别观察各组血清中的肿瘤坏死因子α(TNF -α)、丙二醛(MDA)、超氧化物歧化酶 (SOD)的变化以及病理学的改变。结果 乌司他丁、SASP可使实验性UC大鼠血清中的肿瘤坏死因子α、MDA、含量明显下降 ,SOD活性上升 ,并可明显减轻其结肠急性损伤程度及病理学的改变 ,且乌司他丁组疗效优于SASP组。结论 乌司他丁对UC有明显的治疗作用 ,其可能的机制为抑制炎性细胞因子的释放 ,清除自由基。
Objective To investigate the therapeautic effects of ulinastatin on ulcerative colitis(UC) and it's possible mechanism.Methods Forty adult Wistar rats were randomly divided into four groups;normal group(group A),UC group(group B),SASP(salicylazosulfapyridine) therapeautic therapeutic group(group C),ulinastatin(UTI) therapeautic group(group D). UC models were induced by trinitrophenylmethylnitramine(TNBS), Group A and Group B received 0 9% saline solution instead of ulinastatin and SASP as a control.Serum level of tumor necrotic factor-α(TNF-α),malondialdehyde(MDA),superoxide dismutase(SOD) and pathological change were measured respectively after drugs treatment for two weeks.Results Both UTI and SASP decreased the level of serum TNF-α,MDA ,increased the level of serum SOD ,and relieved mucosa lesion and pathological change in UC rats . UTI was better than SASP in the treatment of UC.Conclusions UTI has apparent therapeautic effects.The mechanism may be associated with inhibition of pro-inflammatory cytokines and clearance of free radicals.
出处
《中国医师杂志》
CAS
2003年第3期342-344,共3页
Journal of Chinese Physician
关键词
溃疡性结肠炎
乌司他丁
肿瘤坏死因子
丙二醛
超氧化物趋化酶
Ulcerative colitis
Ulinastatin
Tumor necrotic factor-α
Malondialdehyde
Superoxide dismutase
Rat
