摘要
目的 探讨蒙古族人血管紧张素转换酶 (ACE)基因多态性与高血压的关系。方法 于 2 0 0 1年 6月 ,在现况调查的基础上 ,选择有高血压家族史的高血压者 5 1例、血压正常者 32例 ,无高血压家族史的高血压者 6 4例、血压正常者 85例作为研究对象。应用多聚酶链式反应 (PCR)技术检测ACE基因的插入 /缺失 (I/D)多态性。用 χ2 检验 ,比较 4组人群ACE基因I/D多态性基因型频率和I、D等位基因频率的差异。结果 ACE基因的 3种基因型 (II、ID、DD)在 4组人群间的分布无显著性差异。在 4组人群中均表现出ID基因型频率最高 ,其次为II基因型 ,DD基因型频率最低。I、D等位基因在 4组人群间的分布也无显著性差异。在 4组人群中I等位基因频率均高于D等位基因频率。结论 ACE基因I/D多态性与蒙古族高血压的发生无关联。
Objective To explore the association between polymorphism of angiotensin-converting enzyme (ACE)gene and hypertension in Mongolian people.Methods On the basis of prevalence survey,fifty-one hypertensives with family history of hypertension,sixty-four hypertensives without family history of hypertension,thirty-two normotensives with family history of hypertension,eighty-five normotensives without family history of hypertension were selected as subjects in June 2001,and polymerase chain reaction (PCR) technique was used to examine the insertion/deletion polymorphism of ACE gene.χ\+2 test was used to compare the differences of I/D polymorphism genetypes frenqency and I/D allele frequency among the four groups.Results There was no significant difference in frequency of ACE genetypes(II/D/DD) among these four groups(P>0.1).Frequency of ID genetype is the highest,then that of II genetype and frequency of DD genetype was the lowest in the all groups.There was also no significant difference in frequency of I and D allele among these four groups.There was a similar phenomenon that frequency of I allele was higher than that of D allele in the all groups.Conclusion The I/D polymorphism of ACE gene was not related to hypertension in Mongolian people.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第4期392-393,共2页
Chinese Journal of Public Health
基金
国家自然科学基金资助项目 (30 0 4 0 0 4 0 )
