摘要
目的 :观察参附注射液对心肌缺血犬血流动力学和对犬、大鼠血压的影响。方法 :结扎犬左冠状动脉前降支造成心肌缺血及低血压 ;缩窄大鼠腹主动脉造成血管阻力增加而形成继发性高血压 ;分别给予参附注射液5 ,10mL·kg-1,观察其对犬血流动力学和对动物正常血压或高血压的影响。结果与结论 :参附注射液使心肌缺血犬的心脏做功能力显著提高 ,在不明显增加心肌耗氧量情况下使心收缩力增强 ,心输出量增加 ;并使心肌缺血所致的血压降低出现明显的回升作用 ;而对继发性高血压和正常动物血压无明显影响。
Objective:To investigate the influence of Shenfu injection on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of dogs and rats. Method:Myocardial ischemic model was made and hypotension in the dogs was induced with ligating left front descending limb coronary artery method, and secondary hypertension by narrowing nephridium artery of rats, Shenfu injection was administered with 5, 10mL·kg -1 to the above dogs and rats separately to investigate the influence of it on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of rats. Result and Conclusion:Shenfu injection enhanced the capacity of myocardial work markedly; it augmented the myocardium contractility and cardiac output without raising the oxygen consume, and at the same time it returned normal the blood pressure in myocardial ischemic; but it had no effects on the normal blood pressure and secondary hypertension of rats.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第3期259-262,共4页
China Journal of Chinese Materia Medica
关键词
参附注射液
心肌缺血
心功能
血流动力学
继发性高血压
Shenfu injection
myocardial ischemic
capacity of cardiac work
hemodynamic
secondary hypertension
