摘要
198 2年Marshall和Wareen首次从慢性活动性胃炎患者的胃粘膜中分离出为幽门螺杆菌 (Hp)。本文概括了Hp与上胃肠道疾病的关系 ,并评估其感染的治疗。现已确认Hp与 4种上胃肠道疾病密切相关 :( 1)慢性胃炎 ;( 2 )消化性溃疡病 ;( 3)胃癌 ;( 4 )胃粘膜相关淋巴样组织(MALT)淋巴瘤。Hp是慢性胃炎的主要病因 ,与消化性溃疡病的发生密切相关 ,Hp感染增加了胃腺癌发生的危险性 ,而且也涉及到胃MALT淋巴瘤发生的致病机理。Hp感染的治疗是以PPI、铋制剂以及RBC为基础的三联疗法 ,当三联疗法失败时则推荐四联疗法。四联疗法是传统的三联疗法 (铋剂为基础的三联疗法 ) +PPI组成。
Obstractive] H. Pylori were firstly cultured by Marshall and Warren from the gastric mucosa of patient with chronic active gastritis in 1982. The article summarizes the relationship between H. pylori and upper gastrointestinal diseases and evaluates the treatment of H. pylori infection. Four diseases have been conformed associating with H. pylori: (1) chronic gastritis; (2) peptic ulcer disease; (3) gastric cancer; (4) gastric MALT lymphoma. It is accepted that H. pylori is the main cause of chronic gastritis and is highly associated with peptic ulcer disease, particularly duodenal ulcer disease. It is also associated with increased risk of gastric adenocarcinoma and seems to be involved in the pathogenesis of gastric MALT lymphoma. The article also summarizes therapy regimens for H. pylori infection. The triple therapies consisting of bismuth, R.B.C and PPI are commonly used for the eradication of H. pylori. If the triple therapies have failed, the quadruple therapy regimen must be used.
出处
《临床内科杂志》
CAS
北大核心
2003年第2期57-59,共3页
Journal of Clinical Internal Medicine
