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EGF与胚胎生长发育 被引量：6

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摘要 表皮生长因子(EGF)对胚胎生长发育有重要作用,通过与胎盘、胎儿各组织器官细胞表面的EGF受体结合调节有丝分裂和其它细胞活动。EGF可促进胎盘细胞增殖、增加绒毛营养摄入、促进滋养细胞合体化及增加胎盘分泌功能;对卵母细胞成熟和受精环节有重要促进作用,可能与早期胚胎生长调节和植入及体外受精结局有关;EGF对胎儿肺、肝、肠、胃、肾上腺等多组织器官生长和成熟有明显促进作用,参与胎儿性别分化调节,缺乏或不足可引起胎儿宫内生长迟缓。
作者 王凤英
机构地区 第三军医大学西南医院妇产科
出处 《国外医学（妇产科学分册）》 2003年第1期26-29,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 EGF 胚胎生长发育 表皮生长因子 体外受精
分类号 R321 [医药卫生—人体解剖和组织胚胎学]
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参考文献19

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  • 2Jojovic M,Wolf F,Mangold U.Epidermal growth factor,vascular endothelial growth factor and progesterone promote placental development in rat whole-embryo culture.Anat Embryol(Berl),1998,198(2):133-139
  • 3Lennard SN,Gerstenberg C,Allen WR,et al.Expression of epidermal growth factor and its receptor in equine placental tissues.J Reprod Fertil,1998,12(1):49-57
  • 4Peters TJ,Chapman BM,Wolfe MW,et al.Placental lactogen-I gene activation in diffetentiating trophoblast cellls:extrinsic and intrinsic regulation involving mitogen-activated protein kinade singaling pathways.J Endocrinol,2000,165(2):443-456
  • 5Zheng J,Bird IM,Melsaether AN,et al.Activation of the mitogen-acrivated protein kinase cascade is necessary but not sufficient for basic fibroblast growth factor-and epidermal growth factor-stimulated expression of endothelial nitric oxide synthase in ovine fetoplacental artery endothelial cells.Endocrinology,1999,140(3):1399-1407
  • 6Goud PT,Goud AP,Qian C,et al.In-vitro maturation of human germinal vesicles stage oocytes:role of cemulus cells and epidermal growth factor in the culture medium.Hum Reprod,1998,13(6):1638-1644
  • 7Illera M J,Lorenzo PL,Illera JC,et al.Developmental competence of immature pig oocytes under the influence of EGF.IGF-I,follicular fluid and gonadotrpins during IVMIVF processes.Int J Dev Biol,1998,42(8):1169-1172
  • 8Hinokio K,Yamano S,Nakagawa K,et al.Lysphosphatidic acid stimulates nuclear and cytoplasmic maturation of golde hamster immature oocytes in ivtro via cumulus cells.Life Sci,2002,70(7):759-767
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  • 10Kheradmand F,Rishi K,Werb Z.Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinaseA/MMP2.J Cell Sci,2002,115(Pt 4):839-848

同被引文献60

引证文献6

二级引证文献18

国外医学（妇产科学分册）
2003年 第1期

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