摘要
目的:探讨 P-gp、GST-π,TOPOⅡ在胃癌组织中的表达及意义。方法:采用免疫组织化学方法研究了 P-gp、GST-π,TOPOⅡ在胃癌组织中的表达情况。结果:P-gp、GST-π在胃癌组织中的表达升高,表达率分别为58.2%和72.84,P-gp 的高表达与淋巴结转移、癌肿浸润深度有关(P<0.05)。GST-π,的高表达与细胞分化程度有关(P<0.05)。TOPOⅡ在胃癌组织中的表达降低,表达率为61.73%,TOPOⅡ的表达降低与临床病理参数无关(P>0.05)。结论:胃癌组织中存在着 P-gp、GST-π,TOPOⅡ表达水平的变化,临床检测 P-gp、GST-π,TOPOⅡ对胃癌化疗方案的制定、判断预后有重要的指导意义。
Objective:To study the expression of P-gp,GST-π,TOPOⅡin Gastric carcinoma and its correlation to clinicopathological features.Methods:The exspression patterns of P-gp,GST-π,TOPOⅡin 81 patients with ex-ophageal careinoma were examined by iummuno-histochemistry SP method using monoclonal antibody to their protein.Results:The positive rates of P-p,GST-πand TOPOⅡwere 58.2%,72.84% and 61.73% respectively.High P-gp was more frequently observed in patient' s with lymph node metastasis and in cancers with deep-muscle and fibro-mem-brane infiltration(P<0.05).High GST-π was more often associated with poor-differentiated than well-differentiated cancers(P<0.05).TOPOⅡexpression was not related to the clinicopathological features(P>0.05).Conclusion:The re-suits suggest that gastric carcinoma express primary multidrug resistance genes.Detecting expression of P-gp,GST-πand TOPOⅡmight play an important role in chemotherapy strategy and might be a useful predictor of prognosis of gastric carcinoma.
出处
《福州总医院学报》
2001年第4期211-213,共3页
Journal of Fuzhou General Hospital
