摘要
目的 :研究急性脑硬死患者血清神经元特异性烯醇化酶 (NSE)和谷胱甘肽 -S -转移酶 (GST)的变化及其临床意义。方法 :应用免疫放射分析 (IRMA)法测定血清NSE含量和应用酶联免疫反应 (ELISA)法测定血清GST含量。结果 :脑梗死患者发病 3天内血清NSE含量高于对照组和 2周时 (p <0 0 1) ,血清GST含量低于对照组和 2周时 (p<0 0 1)。血清NSE含量与神经功能缺损程度呈正相关 (p <0 0 0 1) ,与血清GST含量呈负相关 (p <0 0 5 ) ,也与梗死灶体积有关 (p <0 0 0 1)。结论
Objective To evaluate the variation of serum neuron specific enolase (NSE) and gluathion S transferases (GST) levels in patients with cerebral infarction and its clinical significance. Methods The serum levels of NSE in cerebral infarction patients were determined with immunoradiometric assay (IRMA), and the serum level of GST were determined by enzyme immuno sandwich assay(ELISA). Results Serum NSE levels linked in patints were significantly higher ( p<0 01 ) and GST serum levels were significatly lower ( p <0 01) within 3 days after onset of disease than those at two weeks and those in the controls. There was a positive correlation between serum NSE levels and neurological deficit scores ( p<0 001 ) and a negative correlation with serum GST levels ( p <0 05). There was also a close relationship between the serum NSE levels and the volume of infarction ( p <0 001). Conclusion There was a close relationship between the Serum levels of NSE, GST and clinical features of Patients in the early stage of cerebral infarction.
出处
《放射免疫学杂志》
CAS
2002年第5期259-260,共2页
Journal of Radioimmanology
