摘要
噬菌体肽库展示技术是近年来发展起来的用丝状噬菌体展示外源肽的一项新技术 ,被广泛应用于研究蛋白质与蛋白质之间的相互作用 ,新药的开发等各个领域。该文就该技术的原理。
Phage display is a new technology developed in recent years. Random peptides displayed on the filamentous phage surface offer a rich source of molecular diversity in searching for ligands that bind an antibody, receptor and other proteins. The phage display system has been effective in the discovery of various ligands. Potential applications of the peptide library include investigation of the protein protein interactions and discovery of mimetic drug candidates.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2003年第4期375-378,共4页
Chinese Pharmacological Bulletin
基金
浙江省人民医院"抗移植排斥新药"课题资助NoI2 0 10 9
关键词
噬菌体
先导化合物
靶分子
phage display
peptide libraries
ligands
