摘要
目的 :探讨颌面部上皮样血管内皮瘤的临床病理特点。方法 :回顾性分析 12例上皮样血管内皮瘤的临床资料、组织学特点、治疗结果及预后。全部标本行免疫组织化学SP法染色。结果 :12例中男性患病稍多于女性。肿瘤分别位于舌部、唇部、牙龈、颊部及额部皮肤。通常表现为质韧肿物 ,可伴疼痛、出血。镜下表现 :瘤细胞具有上皮样或组织细胞样形态 ,成巢状、条索状不规则排列 ,分布于粘液样基质中。免疫组织化学检测 ,12例标本波形蛋白及第Ⅷ因子相关抗原阳性。手术治疗后 3例复发 ,未见转移。结论 :口腔颌面部软组织上皮样血管内皮瘤是一种中间型血管肿瘤 ,容易复发 。
Objective: To analyze the clinicopathological features of epitheloid hemangioendothliomas (EHE) in oral and maxillofacial regions. Methods: The clinical data, pathological findings and outcomes of follow up respectively, and all the sections were examined by immunohistochemistry were reviewed. Results: The patients' age ranged from 6 to 73 years(mean 36 years). There was a predilection of male(8/12). Tumors presented at the tongue, lip, gingiva, cheek and skin of forehead. Most of masses were firm and tender on palpation, and bleeding occurred in some cases. Microscopically epitheloid or histiocytoid endothelial cells arranged in nests, cords and irregular patterns were embedded in myohyaline matrix. Immunohistochemical staining showed that tumor cells were positive for Vimentin and factor ⅧRAg. Three cases developed local recurrences after surgical excision while none of them metastasized. Conclusion: EHE in oral and maxillofacial region is a bordline vascular tumor. Recurrence may occurred while metastasis is rare, and long term, follow up should be emphasized.
出处
《武汉大学学报（医学版）》
CAS
2003年第2期200-202,I004,共4页
Medical Journal of Wuhan University
关键词
血管内皮瘤
口腔肿瘤
病理学
免疫组织化学
随访
hemangioendothelioma
pathology
head and neck neoplasms
immunohistochemistry
follow up studies
