摘要
杀手毒素的作用机制与抑制酵母细胞壁 β 葡聚糖合成有关。甘露糖蛋白可能是HM 1的受体之一 ,其抗性的产生是N 糖基化减少所致。HM 1是 88个氨基酸组成的亲水蛋白质 ,C 末端 82和 86位精氨酸对其杀手活性至关重要。
The mechanism of killer toxin is believed to relate to the inhibition of yeast cell wall β glucan synthesis. Mannoprotein probably is one of the receptor for HM 1 killer toxin. The resistance is due to the decrease of N glycosylation of the sensitive yeast strain. HM 1 is a hydrophilic protein consisting of 88 amino acids. Two arginine residues located at positions 82 and 86 in the C terminal region of molecule are essential for the action of killer activity of HM 1 toxin. It is very useful to develop a novel anti fungal agent and prevent wild yeast contamination.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2003年第4期370-374,共5页
Chinese Pharmacological Bulletin
