摘要
目的:探讨多孔β-Ca3(PO4)2(β-TCP)陶瓷的生物降解性能及其植入体内后材料的相关降解机理。方法:本文首先利用CaHPO4·H2O和CaCO3为原料,在960℃、保温1.5h条件下烧结,制得β-TCP陶瓷,结合动物实验对这种材料的生物学性能进行了较为详细的讨论。结果:当材料植入动物体内8周后,与骨组织交界处的材料颗粒开始降解,且外形变得不规则;当材料植入20周后,材料中出现大量分离的细小颗粒,并逐渐被新骨所取代。结论:以这种材料植入体内后将具有优良的生物相容和降解特性,它能诱导骨组织再生,同时自身发生生物降解,是一种非常理想的医用生物材料。
Objective:To probe the biodegradation and its mechanism ofβ-TCP ceramics which were implanted in the body.Method:β-TCP powder as raw material was selected with suitable binder added,and prepared a kind of porous biodegradable ceramics.The biomedical characteristics ofβ-TCP were discussed by means of the animal experiments.Result:When specimen was implanted in the animal for eight weeks,the materials at the border began to degraded and the fringe became irregular.After twenty weeks,the implanted material degraded obviously and was replaced gradually by the new bone.Conclusion:β-TCP ceramics has superior biocompatibility and biodegradability,which can induce the ingrowth of new bone,and become a kind of ideal material for prosthetic applications.Author's address Microelectronic Materials Institute,Dept.of Materials Science and Engineering,Tongji University,Shanghai,200092
出处
《中国康复医学杂志》
CAS
CSCD
2003年第3期166-167,共2页
Chinese Journal of Rehabilitation Medicine
基金
国家自然科学基金资助项目(编号:59493200)
