摘要
Objective: To assess the efficacy and side effects of cyclophosphamide on refractory myasthenic crisis. Methods: Five patients of myasthenic crisis refractory to usual comprehensive treatment, entered an open additional study with cyclophosphamide 200 mg VD q. d or 400 mg VD q. o. d with 6-10 g of total dosage. The patients were followed up for 1-8 years. Results: All the 5 patients were effectively treated with obvious remission in 3 and improvement in 2. Two patients have returned to partial work. The side effects were tolerable. Conclusion: The present clinical trial showed that cyclophosphamide was effective, particularly in a long term as an additional therapy for treating MG patients with refractory crisis of myasthenia gravis.
Objective:To assess the efficacy and side effects of cyclophosphamide on refractory myashenic crisisn.Methods:Five patients of myasthenic crisis refractory to usual comprehensive treatment,entered an open additional study with cyclophosphamide 200 mg VD q.d or 400mg VD q.o.d with 6-10g of total dosage.The patients were followed up for 1-8 years.Results:All the 5 patients were effectively treated with obvious remission in 3 and improvement in 2.Two patients have returned to partial work.The side effects were tolerable.Conclusion:The present clinical trial showed that cyclophosphamide was effective,particularly in a long term as an additional therapy for treating MG patients with refractory crisis of myasthenia gravis.
